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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00675


75 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 protein kinase C activity PRKCG;PRKCE;PRKCD;PRKCQ;PRKCA;PRKCZ;PRKCI;PRKCB 8 1.7E-15 0.022
2 zinc ion binding ESRRG;NR1I2;ESR2;AR;PRKCA;PRKCG;ESR1;PRKCB 8 0.00015 0.21
3 estrogen response element binding ESR1;ESR2 2 0.00033 0.047
4 calcium-independent protein kinase C activity PRKCD;PRKCE 2 0.00033 0.014
5 histone kinase activity (H3-T6 specific) PRKCA;PRKCB 2 0.00038 0.02
6 enzyme binding PRKCE;ESR2;PRKCD;AR;PRKCA;ESR1 6 0.00044 0.19
7 steroid hormone receptor activity ESR1;NR1I2;ESR2;ESRRG 4 0.00046 0.098
8 protein serine/threonine kinase activity PRKCE;PRKCD;PRKCQ;PRKCA;PRKCZ;PRKCI;PRKCB 7 0.00061 0.082
9 calcium-dependent protein kinase C activity PRKCG;PRKCA 2 0.00076 0.02
10 steroid binding ESR1;ESRRG;ESR2 3 0.00088 0.068
11 androgen binding AR;SHBG 2 0.0011 0.042
12 estrogen receptor activity ESR1;ESR2 2 0.0011 0.047
13 protein kinase activity PRKCD;PRKCG;PRKCZ;PRKCI;PRKCA 5 0.0016 0.072
14 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR1I2;AR;ESR2 3 0.0017 0.083
15 beta-catenin binding ESR1;AR 2 0.0029 0.058
16 insulin receptor substrate binding PRKCD;PRKCZ 2 0.0029 0.032
17 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ESRRG;NR1I2 2 0.0059 0.051
18 core promoter sequence-specific DNA binding ESR1;ESR2 2 0.0081 0.065
19 ATPase binding ESR1;AR 2 0.009 0.064
20 enzyme activator activity PRKCD;PRKCE 2 0.01 0.022
21 transcription factor activity, sequence-specific DNA binding ESR1;AR;ESR2 3 0.013 0.11
22 chromatin binding ESR1;AR;PRKCB 3 0.013 0.099
23 receptor activator activity PRKCE 1 0.016 0.014
24 C-8 sterol isomerase activity EBP 1 0.016 0.0068
25 cholestenol delta-isomerase activity EBP 1 0.017 0.0068
26 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1 1 0.018 0.042
27 ATP binding PRKCG;PRKCE;PRKCD;PRKCQ;PRKCA;PRKCZ;PRKCI;PRKCB 8 0.019 0.24
28 RNA polymerase II regulatory region sequence-specific DNA binding ESRRG;NR1I2 2 0.019 0.048
29 RNA polymerase II core promoter proximal region sequence-specific DNA binding ESR1;AR 2 0.024 0.078
30 C3HC4-type RING finger domain binding KCNH2 1 0.024 0.033
31 phosphorelay sensor kinase activity KCNH2 1 0.024 0.035
32 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ESR1;AR 2 0.025 0.078
33 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization KCNH2 1 0.025 0.035
34 androgen receptor activity AR 1 0.026 0.039
35 AF-2 domain binding ESRRG 1 0.027 0.023
36 steroid delta-isomerase activity EBP 1 0.033 0.014
37 receptor antagonist activity ESR2 1 0.033 0.033
38 drug transmembrane transporter activity EBP 1 0.034 0.014
39 transcription coactivator activity NR1I2;ESR2 2 0.034 0.065
40 ethanol binding PRKCE 1 0.034 0.014
41 metal ion binding PRKCD;PRKCQ;PRKCE;PRKCZ;PRKCI 5 0.047 0.2
42 nitric-oxide synthase regulator activity ESR1 1 0.049 0.058
43 retinoic acid receptor activity ESRRG 1 0.049 0.033
44 RNA polymerase II transcription factor binding AR 1 0.056 0.041
45 phospholipase binding PRKCZ 1 0.056 0.036
46 transcription factor binding ESR1;AR 2 0.06 0.078
47 actin monomer binding PRKCE 1 0.063 0.035
48 14-3-3 protein binding PRKCZ 1 0.069 0.024
49 ligand-dependent nuclear receptor transcription coactivator activity PRKCB 1 0.069 0.048
50 histone binding PRKCB 1 0.075 0.025
51 kinase binding PRKCD 1 0.08 0.036
52 ubiquitin-protein transferase activity PRKCQ 1 0.08 0.025
53 androgen receptor binding PRKCB 1 0.094 0.033
54 calcium channel regulator activity PRKCB 1 0.098 0.033
55 inward rectifier potassium channel activity KCNH2 1 0.098 0.035
56 potassium channel regulator activity PRKCZ 1 0.1 0.059
57 DNA binding AR;ESR2 2 0.11 0.12
58 protein kinase C binding PRKCB 1 0.11 0.039
59 protein dimerization activity AR 1 0.12 0.048
60 protein serine/threonine/tyrosine kinase activity PRKCG 1 0.14 0.043
61 delayed rectifier potassium channel activity KCNH2 1 0.14 0.036
62 voltage-gated potassium channel activity KCNH2 1 0.14 0.046
63 scaffold protein binding KCNH2 1 0.15 0.06
64 transcription regulatory region DNA binding AR 1 0.17 0.064
65 protein domain specific binding PRKCZ 1 0.18 0.048
66 phospholipid binding PRKCI 1 0.18 0.046
67 transmembrane signaling receptor activity EBP 1 0.18 0.055
68 non-membrane spanning protein tyrosine kinase activity PRKCD 1 0.23 0.048
69 signal transducer activity PRKCE 1 0.26 0.041
70 identical protein binding ESR1;KCNH2 2 0.27 0.18
71 ubiquitin protein ligase binding KCNH2 1 0.31 0.078
72 drug binding NR1I2 1 0.33 0.19
73 protein kinase binding PRKCZ 1 0.43 0.095
74 receptor binding AR 1 0.44 0.13
75 protein homodimerization activity KCNH2 1 0.68 0.17


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.