QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics   |  Return to main result page
GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

Results: help


Download results

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB14011


76 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 low voltage-gated calcium channel activity CACNA1H;CACNA1I;CACNA1G 3 1.4E-5 0.02
2 cannabinoid receptor activity CNR1;GPR55;CNR2 3 1.4E-5 0.02
3 calcium channel activity TRPM8;TRPV3;TRPV2;TRPV1;TRPV4 5 2.1E-5 0.037
4 extracellular-glycine-gated chloride channel activity GLRA3;GLRB;GLRA1 3 4.2E-5 0.019
5 drug binding CNR1;CHRNA7;GLRB;PPARG;HTR2A 5 0.0022 0.19
6 glycine binding GLRA3;GLRB;GLRA1 3 0.0022 0.031
7 transmitter-gated ion channel activity GLRA1;GLRA3 2 0.0023 0.02
8 G-protein coupled receptor activity GPR55;GPR12;GPR18;OPRM1 4 0.0046 0.061
9 cation channel activity TRPV2;TRPV4 2 0.0058 0.018
10 neuropeptide binding OPRD1;OPRM1 2 0.018 0.039
11 morphine receptor activity OPRM1 1 0.032 0.031
12 serotonin receptor activity HTR1A;HTR2A 2 0.032 0.052
13 temperature-gated cation channel activity TRPA1 1 0.032 0.016
14 enkephalin receptor activity OPRD1 1 0.034 0.025
15 stretch-activated, cation-selective, calcium channel activity TRPV4 1 0.036 0.021
16 taurine binding GLRA1 1 0.038 0.02
17 excitatory extracellular ligand-gated ion channel activity TRPV1 1 0.041 0.021
18 prostaglandin receptor activity PPARG 1 0.043 0.031
19 voltage-gated calcium channel activity CACNA1I;OPRM1 2 0.046 0.039
20 osmosensor activity TRPV4 1 0.046 0.021
21 beta-endorphin receptor activity OPRM1 1 0.05 0.031
22 acetylcholine-gated cation channel activity CHRNA7 1 0.052 0.025
23 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding HTR2A 1 0.052 0.039
24 scaffold protein binding CACNA1H;CACNA1G 2 0.053 0.052
25 ion transmembrane transporter activity TRPV2 1 0.054 0.016
26 G-protein beta-subunit binding OPRM1 1 0.054 0.03
27 extracellular-glycine-gated ion channel activity GLRB 1 0.054 0.018
28 voltage-gated anion channel activity VDAC1 1 0.055 0.019
29 beta-tubulin binding TRPV4 1 0.057 0.017
30 chloride channel regulator activity CHRNA7 1 0.059 0.025
31 G-protein alpha-subunit binding OPRM1 1 0.06 0.035
32 porin activity VDAC1 1 0.062 0.021
33 retinoid X receptor binding PPARG 1 0.064 0.035
34 RNA polymerase II regulatory region DNA binding PPARG 1 0.067 0.032
35 calcium-release channel activity TRPV1 1 0.068 0.022
36 arachidonic acid binding PPARG 1 0.068 0.032
37 intracellular ligand-gated calcium channel activity TRPA1 1 0.069 0.018
38 opioid receptor activity OPRD1 1 0.072 0.032
39 channel activity TRPA1 1 0.082 0.018
40 alpha-tubulin binding TRPV4 1 0.087 0.02
41 toxic substance binding CHRNA7 1 0.087 0.031
42 alpha-actinin binding PPARG 1 0.089 0.039
43 ion channel activity TRPV2 1 0.091 0.023
44 activating transcription factor binding PPARG 1 0.093 0.032
45 SH2 domain binding TRPV4 1 0.099 0.031
46 beta-amyloid binding CHRNA7 1 0.11 0.041
47 ligand-dependent nuclear receptor transcription coactivator activity PPARG 1 0.11 0.039
48 serotonin binding HTR2A 1 0.12 0.052
49 phosphoprotein binding TRPV1 1 0.12 0.032
50 phosphatidylcholine binding GPR12 1 0.12 0.021
51 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding PPARG 1 0.13 0.044
52 acetylcholine receptor activity CHRNA7 1 0.13 0.031
53 core promoter sequence-specific DNA binding PPARG 1 0.14 0.058
54 actin filament binding TRPV4 1 0.15 0.036
55 acetylcholine binding CHRNA7 1 0.16 0.052
56 acetylcholine-activated cation-selective channel activity CHRNA7 1 0.17 0.032
57 protein kinase C binding TRPV4 1 0.17 0.032
58 microtubule binding TRPV4 1 0.21 0.031
59 protein kinase binding VDAC1;TRPV4 2 0.24 0.094
60 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding PPARG 1 0.25 0.081
61 actin binding TRPV4 1 0.25 0.03
62 transcription regulatory region DNA binding PPARG 1 0.25 0.057
63 transmembrane signaling receptor activity TRPV1 1 0.27 0.048
64 virus receptor activity HTR2A 1 0.27 0.053
65 ion channel binding VDAC1 1 0.29 0.057
66 steroid hormone receptor activity PPARG 1 0.29 0.096
67 calmodulin binding TRPV4 1 0.32 0.039
68 transcription factor activity, sequence-specific DNA binding PPARG 1 0.43 0.11
69 chromatin binding PPARG 1 0.44 0.097
70 DNA binding PPARG 1 0.57 0.12
71 enzyme binding PPARG 1 0.66 0.19
72 identical protein binding TRPV4 1 0.83 0.18
73 protein homodimerization activity CHRNA7 1 0.85 0.17
74 zinc ion binding PPARG 1 0.85 0.21
75 metal ion binding CACNA1H 1 0.95 0.2
76 ATP binding TRPV4;TRPV1 2 0.97 0.24


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.