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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00624


26 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 transcription factor activity, sequence-specific DNA binding ESR1;NR3C2;AR 3 0.0002 0.12
2 beta-catenin binding ESR1;AR 2 0.00021 0.11
3 ATPase binding ESR1;AR 2 0.00051 0.093
4 steroid binding ESR1;NR3C2 2 0.00075 0.092
5 RNA polymerase II core promoter proximal region sequence-specific DNA binding ESR1;AR 2 0.0012 0.095
6 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ESR1;AR 2 0.0012 0.095
7 zinc ion binding ESR1;NR3C2;AR 3 0.0013 0.21
8 steroid hormone receptor activity ESR1;NR3C2 2 0.0014 0.11
9 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1 1 0.0028 0.13
10 transcription factor binding ESR1;AR 2 0.0028 0.1
11 chromatin binding ESR1;AR 2 0.0029 0.11
12 estrogen response element binding ESR1 1 0.0043 0.1
13 androgen receptor activity AR 1 0.0043 0.24
14 estrogen receptor activity ESR1 1 0.0071 0.1
15 enzyme binding ESR1;AR 2 0.0071 0.19
16 androgen binding AR 1 0.0074 0.13
17 nitric-oxide synthase regulator activity ESR1 1 0.0082 0.1
18 RNA polymerase II transcription factor binding AR 1 0.0092 0.16
19 core promoter sequence-specific DNA binding ESR1 1 0.017 0.1
20 protein dimerization activity AR 1 0.023 0.12
21 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding AR 1 0.033 0.099
22 transcription regulatory region DNA binding AR 1 0.034 0.092
23 sequence-specific DNA binding NR3C2 1 0.034 0.1
24 DNA binding AR 1 0.097 0.12
25 receptor binding AR 1 0.11 0.13
26 identical protein binding ESR1 1 0.17 0.18


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.