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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00122


29 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 beta-amyloid binding ACHE;CHRNA7;BCHE 3 2.5E-5 0.038
2 N-acylphosphatidylethanolamine-specific phospholipase D activity PLD1;PLD2 2 4.1E-5 0.0053
3 choline-phosphate cytidylyltransferase activity PCYT1A;PCYT1B 2 4.1E-5 0.0042
4 cholinesterase activity ACHE;BCHE 2 5.2E-5 0.023
5 acetylcholinesterase activity ACHE;BCHE 2 6.9E-5 0.024
6 phospholipase D activity PLD1;PLD2 2 0.0001 0.011
7 acetylcholine binding ACHE;CHRNA7 2 0.0023 0.048
8 phosphatidylinositol binding PLD1;PLD2 2 0.0023 0.011
9 phosphocholine phosphatase activity PHOSPHO1 1 0.0083 0.0053
10 phosphoethanolamine phosphatase activity PHOSPHO1 1 0.0083 0.0053
11 serine hydrolase activity ACHE 1 0.013 0.026
12 choline binding BCHE 1 0.013 0.021
13 acetylcholine-gated cation channel activity CHRNA7 1 0.014 0.022
14 chloride channel regulator activity CHRNA7 1 0.016 0.022
15 pyrophosphatase activity PHOSPHO1 1 0.016 0.0042
16 laminin binding ACHE 1 0.026 0.027
17 toxic substance binding CHRNA7 1 0.029 0.026
18 phosphatase activity PHOSPHO1 1 0.032 0.023
19 acetylcholine receptor activity CHRNA7 1 0.047 0.026
20 hydrolase activity ACHE 1 0.057 0.025
21 acetylcholine-activated cation-selective channel activity CHRNA7 1 0.062 0.023
22 collagen binding ACHE 1 0.07 0.038
23 catalytic activity BCHE 1 0.07 0.026
24 lipid binding PCYT1A 1 0.11 0.054
25 protein homodimerization activity ACHE;CHRNA7 2 0.11 0.18
26 drug binding CHRNA7 1 0.19 0.19
27 enzyme binding BCHE 1 0.29 0.19
28 identical protein binding BCHE 1 0.41 0.19
29 metal ion binding PHOSPHO1 1 0.61 0.19


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.