QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics   |  Return to main result page
GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

Results: help


Download results

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB03742


17 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1 1 0.0061 0.23
2 estrogen response element binding ESR1 1 0.0061 0.16
3 estrogen receptor activity ESR1 1 0.0076 0.15
4 nitric-oxide synthase regulator activity ESR1 1 0.0076 0.13
5 beta-catenin binding ESR1 1 0.0085 0.13
6 core promoter sequence-specific DNA binding ESR1 1 0.011 0.11
7 ATPase binding ESR1 1 0.011 0.11
8 steroid binding ESR1 1 0.014 0.11
9 RNA polymerase II core promoter proximal region sequence-specific DNA binding ESR1 1 0.016 0.096
10 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ESR1 1 0.016 0.096
11 steroid hormone receptor activity ESR1 1 0.019 0.11
12 chromatin binding ESR1 1 0.025 0.11
13 transcription factor activity, sequence-specific DNA binding ESR1 1 0.025 0.12
14 transcription factor binding ESR1 1 0.026 0.1
15 enzyme binding ESR1 1 0.044 0.19
16 identical protein binding ESR1 1 0.065 0.19
17 zinc ion binding ESR1 1 0.07 0.21


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.