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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00398


34 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 transmembrane receptor protein tyrosine kinase activity KDR;RET;FLT3;KIT;FLT1;FLT4 6 1.8E-9 0.037
2 vascular endothelial growth factor-activated receptor activity FLT4;FLT3;FLT1;KDR 4 2.1E-8 0.024
3 ATP binding KDR;BRAF;RET;FGFR1;FLT3;RAF1;KIT;FLT1;FLT4;PDGFRB 10 1.1E-6 0.24
4 protein tyrosine kinase activity KDR;PDGFRB;RET;KIT;FGFR1 5 1.2E-5 0.07
5 growth factor binding FLT4;KDR;FLT1 3 1.2E-5 0.023
6 vascular endothelial growth factor binding KDR;PDGFRB 2 0.00039 0.022
7 receptor signaling protein tyrosine kinase activity KDR;KIT 2 0.0015 0.034
8 MAP kinase kinase kinase activity BRAF;RAF1 2 0.005 0.022
9 stem cell factor receptor activity KIT 1 0.0087 0.015
10 platelet-derived growth factor-activated receptor activity PDGFRB 1 0.0087 0.033
11 placental growth factor-activated receptor activity FLT1 1 0.0093 0.015
12 platelet-derived growth factor beta-receptor activity PDGFRB 1 0.01 0.04
13 VEGF-A-activated receptor activity FLT1 1 0.011 0.018
14 VEGF-B-activated receptor activity FLT1 1 0.012 0.021
15 platelet activating factor receptor activity PDGFRB 1 0.016 0.026
16 fibroblast growth factor-activated receptor activity FGFR1 1 0.03 0.017
17 identical protein binding BRAF;RAF1;FGFR1 3 0.039 0.18
18 cytokine binding KIT 1 0.04 0.018
19 protein homodimerization activity FLT3;KIT;FGFR1 3 0.042 0.17
20 Hsp90 protein binding KDR 1 0.042 0.031
21 platelet-derived growth factor receptor binding PDGFRB 1 0.042 0.023
22 fibroblast growth factor binding FGFR1 1 0.042 0.023
23 platelet-derived growth factor binding PDGFRB 1 0.042 0.018
24 cytokine receptor activity FLT3 1 0.05 0.024
25 protein kinase activity BRAF;RAF1 2 0.077 0.07
26 integrin binding KDR 1 0.099 0.04
27 protein phosphatase binding FLT4 1 0.1 0.045
28 calcium ion binding BRAF;RET 2 0.12 0.13
29 heparin binding FGFR1 1 0.18 0.045
30 protein serine/threonine kinase activity BRAF;RAF1 2 0.18 0.084
31 receptor activity RET 1 0.19 0.07
32 protein kinase binding PDGFRB 1 0.3 0.097
33 receptor binding PDGFRB 1 0.31 0.13
34 metal ion binding RAF1;KIT 2 0.31 0.2


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.