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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01805


12 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 cholinesterase activity ACHE 1 0.0064 0.037
2 acetylcholinesterase activity ACHE 1 0.0064 0.037
3 serine hydrolase activity ACHE 1 0.0085 0.083
4 laminin binding ACHE 1 0.013 0.062
5 serine-type endopeptidase activity PRSS2;PRSS1 2 0.013 0.13
6 beta-amyloid binding ACHE 1 0.017 0.049
7 hydrolase activity ACHE 1 0.022 0.046
8 acetylcholine binding ACHE 1 0.022 0.058
9 collagen binding ACHE 1 0.028 0.049
10 calcium ion binding PRSS2 1 0.19 0.13
11 protein homodimerization activity ACHE 1 0.21 0.17
12 metal ion binding PRSS1 1 0.3 0.19


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.