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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB06879


11 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 NADPH-hemoprotein reductase activity NOS2 1 0.0049 0.052
2 arginine binding NOS2 1 0.0049 0.067
3 tetrahydrobiopterin binding NOS2 1 0.0052 0.052
4 FMN binding NOS2 1 0.0078 0.052
5 nitric-oxide synthase activity NOS2 1 0.0078 0.099
6 NADP binding NOS2 1 0.014 0.052
7 flavin adenine dinucleotide binding NOS2 1 0.016 0.059
8 iron ion binding NOS2 1 0.03 0.07
9 heme binding NOS2 1 0.03 0.1
10 receptor binding NOS2 1 0.038 0.13
11 protein homodimerization activity NOS2 1 0.068 0.16


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.