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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01234


46 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity NR3C1 1 0.01 0.031
2 DNA hairpin binding NR0B1 1 0.01 0.0084
3 double-stranded DNA-dependent ATPase activity ANXA1 1 0.012 0.0063
4 glucocorticoid receptor activity NR3C1 1 0.014 0.031
5 steroid hormone receptor binding NR0B1 1 0.016 0.0084
6 AF-2 domain binding NR0B1 1 0.018 0.014
7 annealing helicase activity ANXA1 1 0.02 0.0063
8 phospholipase A2 inhibitor activity ANXA1 1 0.023 0.012
9 arginine binding NOS2 1 0.023 0.04
10 steroid hormone binding NR3C1 1 0.024 0.036
11 NADPH-hemoprotein reductase activity NOS2 1 0.024 0.039
12 nitric-oxide synthase activity NOS2 1 0.025 0.041
13 tetrahydrobiopterin binding NOS2 1 0.025 0.039
14 single-stranded RNA binding ANXA1 1 0.026 0.012
15 protein binding, bridging ANXA1 1 0.027 0.012
16 helicase activity ANXA1 1 0.027 0.012
17 receptor binding NOS2;ANXA1 2 0.027 0.12
18 steroid hormone receptor activity NR1I2;NR0B1 2 0.027 0.099
19 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR1I2;NR0B1 2 0.032 0.085
20 single-stranded DNA binding ANXA1 1 0.033 0.012
21 calcium-dependent phospholipid binding ANXA1 1 0.035 0.018
22 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding NR1I2 1 0.035 0.05
23 FMN binding NOS2 1 0.035 0.048
24 steroid binding NR3C1 1 0.061 0.071
25 calcium-dependent protein binding ANXA1 1 0.061 0.031
26 structural molecule activity ANXA1 1 0.063 0.032
27 zinc ion binding NR1I2;NR3C1 2 0.063 0.21
28 protein homodimerization activity NOS2;NR0B1 2 0.064 0.16
29 RNA polymerase II regulatory region sequence-specific DNA binding NR1I2 1 0.064 0.048
30 flavin adenine dinucleotide binding NOS2 1 0.064 0.06
31 sequence-specific DNA binding NR0B1 1 0.064 0.062
32 protein domain specific binding NR0B1 1 0.065 0.048
33 phospholipid binding ANXA1 1 0.065 0.047
34 NADP binding NOS2 1 0.065 0.048
35 transcription corepressor activity NR0B1 1 0.065 0.032
36 RNA polymerase II core promoter proximal region sequence-specific DNA binding NR3C1 1 0.065 0.079
37 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding NR3C1 1 0.066 0.079
38 transcription coactivator activity NR1I2 1 0.078 0.065
39 transcription factor binding NR0B1 1 0.11 0.081
40 transcription factor activity, sequence-specific DNA binding NR3C1 1 0.11 0.11
41 heme binding NOS2 1 0.12 0.099
42 drug binding NR1I2 1 0.12 0.19
43 iron ion binding NOS2 1 0.13 0.071
44 RNA binding NR0B1 1 0.14 0.032
45 DNA binding NR0B1 1 0.15 0.12
46 calcium ion binding ANXA1 1 0.25 0.12


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.