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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB03882


12 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 estrogen receptor activity ESR2 1 0.0057 0.11
2 receptor antagonist activity ESR2 1 0.0057 0.13
3 estrogen response element binding ESR2 1 0.0064 0.11
4 core promoter sequence-specific DNA binding ESR2 1 0.013 0.099
5 steroid binding ESR2 1 0.015 0.099
6 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding ESR2 1 0.018 0.12
7 transcription coactivator activity ESR2 1 0.02 0.11
8 steroid hormone receptor activity ESR2 1 0.02 0.13
9 transcription factor activity, sequence-specific DNA binding ESR2 1 0.027 0.13
10 DNA binding ESR2 1 0.037 0.13
11 enzyme binding ESR2 1 0.042 0.2
12 zinc ion binding ESR2 1 0.07 0.21


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.