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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB11755


11 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 cannabinoid receptor activity CNR1;GPR55;CNR2 3 1.0E-7 0.0083
2 calcium channel activity TRPM8;TRPV2 2 0.0055 0.03
3 temperature-gated cation channel activity TRPA1 1 0.0091 0.008
4 intracellular ligand-gated calcium channel activity TRPA1 1 0.016 0.008
5 ion transmembrane transporter activity TRPV2 1 0.016 0.008
6 cation channel activity TRPV2 1 0.02 0.0072
7 channel activity TRPA1 1 0.02 0.0072
8 ion channel activity TRPV2 1 0.02 0.0088
9 serotonin receptor activity HTR1A 1 0.051 0.049
10 G-protein coupled receptor activity GPR55 1 0.12 0.056
11 drug binding CNR1 1 0.15 0.19


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.