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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB07080


32 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 transcription coactivator activity NR1H3;RXRB;NCOA2;NCOA1;NR1I2 5 5.7E-8 0.07
2 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding RXRB;NR1H3;NR1H2;NR1I2 4 1.2E-6 0.088
3 steroid hormone receptor activity RXRB;NR1H3;NR1H2;NR1I2 4 2.8E-6 0.1
4 ligand-dependent nuclear receptor binding NCOA2;NCOA1 2 0.0003 0.028
5 histone acetyltransferase activity NCOA2;NCOA1 2 0.00048 0.031
6 ligand-dependent nuclear receptor transcription coactivator activity NCOA2;NCOA1 2 0.00048 0.05
7 nuclear hormone receptor binding NCOA2;NCOA1 2 0.00051 0.028
8 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding RXRB;NR1I2 2 0.00068 0.054
9 zinc ion binding RXRB;NR1H3;NR1H2;NR1I2 4 0.0011 0.21
10 RNA polymerase II regulatory region sequence-specific DNA binding RXRB;NR1I2 2 0.003 0.05
11 RNA polymerase II core promoter proximal region sequence-specific DNA binding NCOA2;NR1H2 2 0.0035 0.083
12 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding NR1H2 1 0.0057 0.026
13 thyroid hormone receptor coactivator activity NCOA2 1 0.0091 0.024
14 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding NCOA2 1 0.0091 0.026
15 sterol response element binding NR1H3 1 0.0098 0.019
16 9-cis retinoic acid receptor activity RXRB 1 0.011 0.03
17 apolipoprotein A-I receptor binding NR1H2 1 0.011 0.019
18 RNA polymerase II regulatory region DNA binding NCOA1 1 0.011 0.039
19 chromatin binding NCOA2;NCOA1 2 0.012 0.1
20 RNA polymerase II transcription coactivator activity NCOA1 1 0.014 0.034
21 DNA binding NR1H3;NR1H2 2 0.02 0.12
22 androgen receptor binding NCOA1 1 0.037 0.033
23 ATPase binding NR1H2 1 0.038 0.068
24 RNA polymerase II distal enhancer sequence-specific DNA binding RXRB 1 0.039 0.029
25 cholesterol binding NR1H3 1 0.041 0.024
26 protein N-terminus binding NCOA1 1 0.044 0.043
27 transcription regulatory region DNA binding NR1H3 1 0.064 0.068
28 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding NR1H2 1 0.064 0.083
29 sequence-specific DNA binding NR1H3 1 0.064 0.068
30 transcription factor activity, sequence-specific DNA binding RXRB 1 0.12 0.11
31 drug binding NR1I2 1 0.14 0.19
32 enzyme binding NCOA1 1 0.21 0.19


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.