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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB06732


37 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 RNA polymerase II core promoter proximal region sequence-specific DNA binding ESR1;ESRRA;NR2F1 3 0.00011 0.085
2 sequence-specific DNA binding ESRRA;AHR;NR2F1 3 0.00011 0.083
3 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding ESRRA;AHR;NR2F1 3 0.00013 0.091
4 steroid hormone receptor activity ESR1;ESRRA;NR2F1 3 0.00015 0.1
5 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ESRRA;NR2F1 2 0.00028 0.051
6 transcription factor activity, sequence-specific DNA binding ESR1;AHR;NR2F1 3 0.00045 0.11
7 steroid binding ESR1;ESRRA 2 0.002 0.079
8 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ESR1;ESRRA 2 0.004 0.085
9 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1 1 0.0073 0.066
10 estrogen response element binding ESR1 1 0.01 0.069
11 E-box binding AHR 1 0.01 0.071
12 transcription factor binding ESR1;AHR 2 0.011 0.087
13 zinc ion binding ESR1;ESRRA;NR2F1 3 0.011 0.21
14 enhancer binding AHR 1 0.013 0.065
15 retinoic acid-responsive element binding NR2F1 1 0.013 0.052
16 estrogen receptor activity ESR1 1 0.016 0.069
17 DNA binding ESRRA;AHR 2 0.018 0.11
18 nitric-oxide synthase regulator activity ESR1 1 0.018 0.081
19 beta-catenin binding ESR1 1 0.023 0.081
20 Hsp90 protein binding AHR 1 0.023 0.066
21 aromatase activity CYP1B1 1 0.034 0.05
22 core promoter sequence-specific DNA binding ESR1 1 0.034 0.081
23 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP1B1 1 0.034 0.045
24 ATPase binding ESR1 1 0.035 0.078
25 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding AHR 1 0.039 0.051
26 protein dimerization activity AHR 1 0.041 0.076
27 monooxygenase activity CYP1B1 1 0.041 0.045
28 oxygen binding CYP1B1 1 0.049 0.066
29 transcription regulatory region DNA binding AHR 1 0.06 0.078
30 protein domain specific binding ESRRA 1 0.065 0.073
31 transcription coactivator activity NR2F1 1 0.077 0.084
32 chromatin binding ESR1 1 0.11 0.1
33 heme binding CYP1B1 1 0.12 0.1
34 iron ion binding CYP1B1 1 0.13 0.079
35 protein heterodimerization activity AHR 1 0.13 0.1
36 enzyme binding ESR1 1 0.18 0.19
37 identical protein binding ESR1 1 0.27 0.18


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.