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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB13873


30 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding PPARA;NR1I2;PPARD;PPARG 4 7.3E-7 0.09
2 steroid hormone receptor activity PPARA;NR1I2;PPARD;PPARG 4 1.3E-6 0.1
3 zinc ion binding PPARA;NR1I2;PPARD;PPARG;mmp20 5 1.2E-5 0.21
4 drug binding PPARA;NR1I2;PPARD;PPARG 4 1.2E-5 0.19
5 transcription factor activity, sequence-specific DNA binding PPARA;PPARD;PPARG 3 0.00044 0.11
6 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding NR1I2;PPARG 2 0.00057 0.061
7 DNA binding PPARA;PPARD;PPARG 3 0.0011 0.12
8 sequence-specific DNA binding PPARA;PPARD 2 0.0035 0.075
9 linoleic acid binding PPARD 1 0.0045 0.12
10 prostaglandin receptor activity PPARG 1 0.0045 0.062
11 ubiquitin conjugating enzyme binding PPARA 1 0.0049 0.1
12 lipid binding PPARA;PPARD 2 0.0049 0.072
13 RNA polymerase II regulatory region DNA binding PPARG 1 0.011 0.057
14 retinoid X receptor binding PPARG 1 0.011 0.06
15 arachidonic acid binding PPARG 1 0.013 0.062
16 RNA polymerase II repressing transcription factor binding PPARA 1 0.013 0.066
17 transcriptional activator activity, RNA polymerase II transcription factor binding PPARA 1 0.016 0.073
18 alpha-actinin binding PPARG 1 0.016 0.061
19 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding PPARA 1 0.016 0.086
20 activating transcription factor binding PPARG 1 0.017 0.057
21 ligand-dependent nuclear receptor transcription coactivator activity PPARG 1 0.02 0.057
22 core promoter sequence-specific DNA binding PPARG 1 0.029 0.07
23 RNA polymerase II regulatory region sequence-specific DNA binding NR1I2 1 0.053 0.057
24 transcription regulatory region DNA binding PPARG 1 0.054 0.07
25 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding PPARA 1 0.054 0.085
26 RNA polymerase II core promoter proximal region sequence-specific DNA binding PPARA 1 0.057 0.085
27 metalloendopeptidase activity mmp20 1 0.071 0.059
28 transcription coactivator activity NR1I2 1 0.071 0.075
29 chromatin binding PPARG 1 0.1 0.1
30 enzyme binding PPARG 1 0.18 0.19


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.