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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB07863


33 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 ligand-dependent nuclear receptor transcription coactivator activity NCOA2;PPARG 2 0.0007 0.048
2 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding PPARG;RXRA 2 0.0038 0.091
3 transcription coactivator activity NCOA2;RXRA 2 0.0042 0.068
4 steroid hormone receptor activity PPARG;RXRA 2 0.0042 0.1
5 chromatin binding NCOA2;PPARG 2 0.0059 0.1
6 transcription factor activity, sequence-specific DNA binding PPARG;RXRA 2 0.0059 0.11
7 prostaglandin receptor activity PPARG 1 0.0064 0.04
8 retinoic acid-responsive element binding RXRA 1 0.007 0.058
9 9-cis retinoic acid receptor activity RXRA 1 0.007 0.047
10 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding NCOA2 1 0.0071 0.037
11 thyroid hormone receptor coactivator activity NCOA2 1 0.0071 0.037
12 retinoid X receptor binding PPARG 1 0.0076 0.044
13 vitamin D receptor binding RXRA 1 0.0078 0.087
14 RNA polymerase II regulatory region DNA binding PPARG 1 0.0081 0.04
15 DNA binding PPARG;RXRA 2 0.0082 0.12
16 arachidonic acid binding PPARG 1 0.0085 0.04
17 enzyme binding PPARG;RXRA 2 0.0085 0.19
18 ligand-dependent nuclear receptor binding NCOA2 1 0.0093 0.038
19 retinoic acid receptor activity RXRA 1 0.0093 0.044
20 activating transcription factor binding PPARG 1 0.01 0.04
21 alpha-actinin binding PPARG 1 0.01 0.05
22 nuclear hormone receptor binding NCOA2 1 0.011 0.04
23 histone acetyltransferase activity NCOA2 1 0.012 0.048
24 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding PPARG 1 0.014 0.053
25 chromatin DNA binding RXRA 1 0.014 0.038
26 core promoter sequence-specific DNA binding PPARG 1 0.016 0.067
27 zinc ion binding PPARG;RXRA 2 0.017 0.21
28 RNA polymerase II regulatory region sequence-specific DNA binding RXRA 1 0.029 0.048
29 RNA polymerase II core promoter proximal region sequence-specific DNA binding NCOA2 1 0.031 0.085
30 transcription regulatory region DNA binding PPARG 1 0.031 0.067
31 sequence-specific DNA binding RXRA 1 0.032 0.066
32 drug binding PPARG 1 0.07 0.19
33 protein heterodimerization activity RXRA 1 0.078 0.1


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.