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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB09285


15 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 leukotriene B4 receptor activity LTB4R 1 0.0085 0.0068
2 prostaglandin-endoperoxide synthase activity PTGS2 1 0.0085 0.044
3 arachidonate 15-lipoxygenase activity PTGS2 1 0.011 0.03
4 thromboxane A2 receptor activity TBXA2R 1 0.011 0.0068
5 arachidonate 5-lipoxygenase activity ALOX5 1 0.011 0.015
6 leukotriene receptor activity LTB4R 1 0.014 0.014
7 guanyl-nucleotide exchange factor activity TBXA2R 1 0.018 0.03
8 G-protein coupled peptide receptor activity LTB4R 1 0.024 0.021
9 peroxidase activity PTGS2 1 0.024 0.044
10 nucleotide binding LTB4R 1 0.046 0.04
11 lipid binding PTGS2 1 0.067 0.061
12 heme binding PTGS2 1 0.11 0.097
13 iron ion binding ALOX5 1 0.11 0.064
14 enzyme binding PTGS2 1 0.16 0.19
15 metal ion binding PTGS2 1 0.38 0.19


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.