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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01016


37 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 ATPase activity, coupled to transmembrane movement of substances ABCC9;ABCA1;ABCC8 3 0.00014 0.014
2 sulfonylurea receptor activity ABCC9;ABCC8 2 0.00017 0.0059
3 ATP-activated inward rectifier potassium channel activity KCNJ11;KCNJ8 2 0.00067 0.0079
4 ion channel binding KCNJ11;ABCC9;ABCC8 3 0.0011 0.051
5 ATP binding KCNJ11;CFTR;KCNJ8;ABCB11;ABCA1;ABCC9;ABCC8 7 0.0023 0.24
6 potassium channel activity ABCC9;ABCC8 2 0.0031 0.012
7 apolipoprotein A-I receptor activity ABCA1 1 0.0074 0.004
8 bile acid-exporting ATPase activity ABCB11 1 0.0074 0.004
9 canalicular bile acid transmembrane transporter activity ABCB11 1 0.0079 0.0051
10 anion transmembrane transporter activity ABCA1 1 0.0085 0.0067
11 chloride channel inhibitor activity CFTR 1 0.0091 0.0055
12 transporter activity ABCC9;ABCB11 2 0.0094 0.035
13 chloride transmembrane transporter activity CFTR 1 0.0099 0.0055
14 ATP-binding and phosphorylation-dependent chloride channel activity CFTR 1 0.011 0.0058
15 channel-conductance-controlling ATPase activity CFTR 1 0.012 0.0063
16 carnitine O-palmitoyltransferase activity CPT1A 1 0.013 0.0045
17 sodium-exporting ATPase activity, phosphorylative mechanism ABCB11 1 0.013 0.01
18 bicarbonate transmembrane transporter activity CFTR 1 0.015 0.0067
19 apolipoprotein A-I binding ABCA1 1 0.018 0.0042
20 small GTPase binding ABCA1 1 0.018 0.0042
21 phospholipid transporter activity ABCA1 1 0.028 0.0061
22 ankyrin binding KCNJ11 1 0.031 0.02
23 G-protein activated inward rectifier potassium channel activity KCNJ5 1 0.031 0.0047
24 potassium ion binding KCNJ11 1 0.032 0.014
25 syntaxin binding ABCA1 1 0.032 0.011
26 cholesterol transporter activity ABCA1 1 0.033 0.0045
27 apolipoprotein binding ABCA1 1 0.043 0.011
28 ATPase binding ABCA1 1 0.052 0.051
29 inward rectifier potassium channel activity KCNJ8 1 0.052 0.019
30 potassium channel regulator activity ABCC9 1 0.054 0.044
31 cholesterol binding ABCA1 1 0.056 0.011
32 PDZ domain binding CFTR 1 0.072 0.031
33 voltage-gated potassium channel activity KCNJ11 1 0.077 0.031
34 chloride channel activity CFTR 1 0.081 0.037
35 phospholipid binding ABCA1 1 0.098 0.031
36 receptor binding ABCA1 1 0.28 0.12
37 enzyme binding CFTR 1 0.3 0.19


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.