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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01812


16 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 sulfotransferase activity SULT1A1;SULT1B1;HS3ST3A1;SULT1E1;SULT2A1;HS3ST1 6 5.0E-15 0.0032
2 steroid sulfotransferase activity SULT1A1;SULT2B1;SULT1E1 3 2.6E-7 0.0026
3 aryl sulfotransferase activity SULT1B1;SULT1A1 2 4.6E-5 0.0019
4 flavonol 3-sulfotransferase activity SULT1A1;SULT1E1 2 4.6E-5 0.0018
5 ribonuclease A activity RNASE1;RNASE2 2 0.00011 0.006
6 nucleic acid binding RNASE1;RNASE2 2 0.0016 0.0089
7 alcohol sulfotransferase activity SULT2B1 1 0.0048 0.0019
8 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity HS3ST1 1 0.0048 0.0015
9 estrone sulfotransferase activity SULT1E1 1 0.0052 0.0019
10 [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity HS3ST3A1 1 0.0057 0.0018
11 bile-salt sulfotransferase activity SULT2A1 1 0.0063 0.0023
12 [heparan sulfate]-glucosamine N-sulfotransferase activity NDST1 1 0.0071 0.0015
13 deacetylase activity NDST1 1 0.017 0.0056
14 ribonuclease activity RNASE2 1 0.02 0.0026
15 endonuclease activity RNASE2 1 0.026 0.0026
16 steroid binding SULT1E1 1 0.062 0.05


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.