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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00233


17 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 arachidonate 15-lipoxygenase activity PTGS2 1 0.016 0.06
2 prostaglandin-endoperoxide synthase activity PTGS2 1 0.016 0.084
3 IkappaB kinase activity CHUK 1 0.018 0.031
4 arachidonate 5-lipoxygenase activity ALOX5 1 0.024 0.034
5 phospholipase A2 activity PLA2G2E 1 0.039 0.055
6 peroxidase activity PTGS2 1 0.04 0.084
7 scaffold protein binding CHUK 1 0.079 0.095
8 lipid binding PTGS2 1 0.1 0.095
9 protein heterodimerization activity CHUK 1 0.16 0.12
10 iron ion binding ALOX5 1 0.16 0.091
11 heme binding PTGS2 1 0.16 0.12
12 enzyme binding PTGS2 1 0.19 0.2
13 protein kinase activity CHUK 1 0.19 0.091
14 calcium ion binding PLA2G2E 1 0.25 0.14
15 protein homodimerization activity CHUK 1 0.28 0.19
16 metal ion binding PTGS2 1 0.4 0.2
17 ATP binding CHUK 1 0.59 0.24


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.