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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00145


70 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 glycine binding GLDC;GSS;GLRA1;GRIN3B;ALAS2;GNMT;GLRA3;GLRB;GLRA2 9 3.3E-14 0.018
2 extracellular-glycine-gated chloride channel activity GLRA3;GLRA2;GLRB;GLRA1 4 4.3E-7 0.0064
3 pyridoxal phosphate binding AGXT;GCAT;ALAS1;AGXT2;SHMT2;ALAS2;NA;SHMT1 8 1.7E-6 0.027
4 glycine N-acyltransferase activity GLYATL2;GLYATL1;GLYAT 3 1.4E-5 0.0018
5 glycine hydroxymethyltransferase activity SHMT1;SHMT2;NA 3 1.4E-5 0.0029
6 transmitter-gated ion channel activity GLRA1;GLRA2;GLRA3 3 1.7E-5 0.0066
7 NMDA glutamate receptor activity GRIN2A;GRIN3B;GRIN2C 3 0.00066 0.013
8 L-allo-threonine aldolase activity SHMT1;SHMT2 2 0.00075 0.0029
9 alanine-glyoxylate transaminase activity AGXT2;AGXT 2 0.00075 0.0034
10 glycine transmembrane transporter activity SLC32A1;SLC36A1 2 0.00083 0.0017
11 glycine SLC6A9;SLC6A5 2 0.00092 0.0032
12 5-aminolevulinate synthase activity ALAS2;ALAS1 2 0.0021 0.0016
13 neurotransmitter binding GRIN2A;GRIN3B 2 0.0038 0.0082
14 extracellular-glutamate-gated ion channel activity GRIN2A;GRIN3B;GRIN2C 3 0.0045 0.023
15 cation channel activity GRIN3B;GRIN2C 2 0.0054 0.0065
16 neurotransmitter SLC6A9;SLC6A5 2 0.018 0.0031
17 serine-pyruvate transaminase activity AGXT 1 0.021 0.003
18 glycine N-benzoyltransferase activity GLYAT 1 0.021 0.0011
19 L-pipecolate oxidase activity PIPOX 1 0.022 0.0011
20 long-chain acyl-CoA hydrolase activity BAAT 1 0.023 0.0012
21 glycine amidinotransferase activity GATM 1 0.023 0.0029
22 taurine binding GLRA1 1 0.024 0.0065
23 amino acid binding SHMT2;AGXT 2 0.024 0.011
24 glycine N-choloyltransferase activity BAAT 1 0.025 0.0013
25 glutathione synthase activity GSS 1 0.026 0.003
26 N-acyltransferase activity BAAT 1 0.027 0.0014
27 glycine C-acetyltransferase activity GCAT 1 0.028 0.0016
28 very long chain acyl-CoA hydrolase activity BAAT 1 0.029 0.0016
29 glycine dehydrogenase (decarboxylating) activity GLDC 1 0.03 0.0018
30 sarcosine oxidase activity PIPOX 1 0.031 0.0021
31 glutamine N-acyltransferase activity GLYATL1 1 0.032 0.0025
32 glycine N-methyltransferase activity GNMT 1 0.034 0.0023
33 medium-chain acyl-CoA hydrolase activity BAAT 1 0.035 0.0042
34 calcium channel activity GRIN2A;GRIN3B 2 0.037 0.026
35 palmitoyl-CoA hydrolase activity BAAT 1 0.037 0.0021
36 aminomethyltransferase activity GCSH 1 0.037 0.0029
37 glycine-tRNA ligase activity GARS 1 0.037 0.0064
38 serine binding SHMT1 1 0.038 0.0032
39 neurotransmitter receptor activity GRIN3B 1 0.038 0.0059
40 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity AGXT2 1 0.039 0.0024
41 beta-alanine-pyruvate transaminase activity AGXT2 1 0.041 0.0025
42 extracellular-glycine-gated ion channel activity GLRB 1 0.043 0.0032
43 L-alanine transmembrane transporter activity SLC36A1 1 0.05 0.0022
44 L-proline transmembrane transporter activity SLC36A1 1 0.05 0.0021
45 voltage-gated cation channel activity GRIN2A 1 0.051 0.0082
46 hydrogen SLC36A1 1 0.052 0.0032
47 amino acid transmembrane transporter activity SLC32A1 1 0.065 0.0027
48 carboxylic ester hydrolase activity BAAT 1 0.074 0.0065
49 gamma-aminobutyric acid SLC32A1 1 0.074 0.0022
50 transferase activity, transferring acyl groups GLYAT 1 0.076 0.0031
51 hydrogen ion transmembrane transporter activity SLC36A1 1 0.077 0.004
52 lyase activity GLDC 1 0.087 0.003
53 coenzyme binding ALAS2 1 0.094 0.0064
54 transaminase activity AGXT 1 0.094 0.0049
55 folic acid binding GNMT 1 0.095 0.015
56 methyltransferase activity NA 1 0.097 0.0051
57 protein self-association AGXT 1 0.1 0.0067
58 glutathione binding GSS 1 0.1 0.0061
59 receptor binding BAAT;AGXT;PIPOX 3 0.11 0.12
60 glutamate binding GRIN2A 1 0.13 0.0093
61 protein dimerization activity GARS 1 0.2 0.029
62 protein homodimerization activity SHMT1;AGXT;GSS 3 0.4 0.17
63 G-protein coupled receptor activity GPR18 1 0.44 0.056
64 electron carrier activity GLDC 1 0.52 0.036
65 chromatin binding SHMT2 1 0.52 0.094
66 drug binding GLRB 1 0.55 0.19
67 magnesium ion binding GSS 1 0.62 0.043
68 identical protein binding AGXT2 1 0.89 0.17
69 zinc ion binding GRIN2A 1 0.91 0.21
70 ATP binding GARS;GSS 2 0.99 0.24


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.