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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00167


13 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 L-isoleucine transaminase activity BCAT2;BCAT1 2 6.6E-6 0.0035
2 branched-chain-amino-acid transaminase activity BCAT2;BCAT1 2 6.6E-6 0.003
3 L-leucine transaminase activity BCAT2;BCAT1 2 8.3E-6 0.0043
4 isoleucine-tRNA ligase activity IARS2;IARS 2 1.1E-5 0.0047
5 L-valine transaminase activity BCAT2;BCAT1 2 1.7E-5 0.0053
6 aminoacyl-tRNA editing activity IARS2;IARS 2 8.2E-5 0.0071
7 acyl-CoA dehydrogenase activity ACADSB 1 0.016 0.0027
8 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor ACADSB 1 0.017 0.0027
9 GTPase binding IARS 1 0.018 0.014
10 fatty-acyl-CoA binding ACADSB 1 0.03 0.0042
11 flavin adenine dinucleotide binding ACADSB 1 0.058 0.041
12 electron carrier activity ACADSB 1 0.11 0.037
13 ATP binding IARS2;IARS 2 0.26 0.24


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.