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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00182


39 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 epinephrine binding ADRA2A;ADRA2C;ADRB2;ADRB3;ADRB1;ADRA2B 6 1.6E-12 0.047
2 norepinephrine binding ADRB1;ADRA2A;ADRB2;ADRB3 4 2.9E-8 0.048
3 monoamine transmembrane transporter activity SLC6A4;SLC18A2;SLC6A2;SLC6A3 4 9.7E-8 0.039
4 alpha1-adrenergic receptor activity ADRA1A;ADRA1B;ADRA1D 3 2.1E-6 0.04
5 alpha2-adrenergic receptor activity ADRA2A;ADRA2B;ADRA2C 3 2.1E-6 0.043
6 dopamine binding ADRB2;DRD2;SLC6A3 3 9.4E-5 0.058
7 beta-adrenergic receptor activity ADRB1;ADRB3 2 0.00024 0.043
8 protein heterodimerization activity ADRB1;ADRA2A;ADRA1B;ADRA1A;ADRA2C 5 0.0005 0.095
9 alpha-2A adrenergic receptor binding ADRB1;ADRA2C 2 0.0017 0.041
10 primary amine oxidase activity MAOB;MAOA 2 0.0017 0.076
11 alpha-1B adrenergic receptor binding ADRA2A 1 0.011 0.04
12 cocaine binding SLC6A4 1 0.011 0.053
13 Ras guanyl-nucleotide exchange factor activity ADRB1 1 0.012 0.043
14 beta2-adrenergic receptor activity ADRB2 1 0.013 0.043
15 norepinephrine SLC6A2 1 0.013 0.066
16 potassium channel regulator activity ADRB2;DRD2 2 0.013 0.047
17 serotonin SLC6A4 1 0.014 0.058
18 trace-amine receptor activity TAAR1 1 0.015 0.028
19 dopamine transmembrane transporter activity SLC6A3 1 0.016 0.08
20 beta1-adrenergic receptor activity ADRB1 1 0.016 0.043
21 beta3-adrenergic receptor activity ADRB3 1 0.018 0.11
22 dopamine SLC6A3 1 0.019 0.08
23 heterotrimeric G-protein binding ADRA2A 1 0.02 0.042
24 alpha-2C adrenergic receptor binding ADRA2A 1 0.021 0.04
25 serotonin transmembrane transporter activity SLC6A4 1 0.021 0.05
26 flavin adenine dinucleotide binding MAOB;MAOA 2 0.022 0.048
27 dopamine neurotransmitter receptor activity, coupled via Gi/Go DRD2 1 0.029 0.039
28 thioesterase binding ADRA2A 1 0.047 0.041
29 protein homodimerization activity ADRA2A;ADRB2;ADRB3;ADRA2C 4 0.047 0.16
30 Rab GTPase binding SLC6A4 1 0.052 0.047
31 serotonin binding MAOA 1 0.075 0.049
32 drug binding ADRB2;DRD2 2 0.085 0.19
33 receptor signaling protein activity ADRB1 1 0.085 0.042
34 actin filament binding SLC6A4 1 0.097 0.043
35 PDZ domain binding ADRB1 1 0.14 0.041
36 G-protein coupled receptor activity TAAR1 1 0.29 0.058
37 electron carrier activity MAOB 1 0.34 0.045
38 protein kinase binding ADRA2A 1 0.48 0.089
39 identical protein binding DRD2 1 0.7 0.17


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.