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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB11633


43 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 scaffold protein binding KCNA5;KCNH2;KCNQ1;SCN5A 4 1.8E-5 0.049
2 ion channel binding KCNJ11;KCNQ1;KCND3;SCN5A 4 4.1E-5 0.055
3 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization KCNH2;KCNQ1 2 9.8E-5 0.019
4 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization KCNA5;KCNQ1 2 9.8E-5 0.0067
5 voltage-gated potassium channel activity KCNJ11;KCNH2;KCNQ1 3 0.00024 0.033
6 delayed rectifier potassium channel activity KCNA5;KCNH2;KCNQ1 3 0.00024 0.02
7 outward rectifier potassium channel activity KCNA5;KCNQ1 2 0.00034 0.007
8 ankyrin binding KCNJ11;SCN5A 2 0.00059 0.021
9 G-protein activated inward rectifier potassium channel activity KCNJ9;KCNJ6 2 0.00059 0.0068
10 alpha-actinin binding CACNA1C;KCNA5 2 0.00065 0.033
11 calmodulin binding CACNA1C;KCNQ1;SCN5A 3 0.00077 0.034
12 inward rectifier potassium channel activity KCNH2;KCNJ6 2 0.0025 0.02
13 voltage-gated potassium channel activity involved in SA node cell action potential repolarization KCNA5 1 0.0077 0.01
14 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization KCNQ1 1 0.0077 0.0098
15 voltage-gated sodium channel activity involved in bundle of His cell action potential SCN5A 1 0.0081 0.018
16 voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization KCNA5 1 0.0086 0.012
17 voltage-gated sodium channel activity involved in AV node cell action potential SCN5A 1 0.0092 0.018
18 voltage-gated sodium channel activity involved in SA node cell action potential SCN5A 1 0.0098 0.02
19 protein phosphatase 1 binding KCNQ1 1 0.011 0.0078
20 nitric-oxide synthase binding SCN5A 1 0.011 0.016
21 C3HC4-type RING finger domain binding KCNH2 1 0.011 0.018
22 potassium channel inhibitor activity KCNA5 1 0.012 0.0078
23 voltage-gated sodium channel activity involved in Purkinje myocyte action potential SCN5A 1 0.013 0.016
24 A-type (transient outward) potassium channel activity KCND3 1 0.013 0.0067
25 phosphorelay sensor kinase activity KCNH2 1 0.014 0.02
26 protein kinase A regulatory subunit binding KCNQ1 1 0.016 0.019
27 ATP-activated inward rectifier potassium channel activity KCNJ11 1 0.02 0.016
28 ubiquitin protein ligase binding KCNH2;SCN5A 2 0.022 0.07
29 voltage-gated sodium channel activity involved in cardiac muscle cell action potential SCN5A 1 0.024 0.017
30 potassium ion binding KCNJ11 1 0.032 0.018
31 phosphatidylinositol-4,5-bisphosphate binding KCNQ1 1 0.034 0.018
32 fibroblast growth factor binding SCN5A 1 0.034 0.02
33 protein kinase A catalytic subunit binding KCNQ1 1 0.037 0.02
34 high voltage-gated calcium channel activity CACNA1C 1 0.04 0.02
35 protein kinase binding KCNA5;SCN5A 2 0.04 0.091
36 voltage-gated sodium channel activity SCN5A 1 0.053 0.02
37 voltage-gated calcium channel activity CACNA1C 1 0.076 0.034
38 protein domain specific binding SCN5A 1 0.1 0.034
39 metal ion binding CACNA1C;KCND3 2 0.29 0.19
40 enzyme binding SCN5A 1 0.32 0.19
41 identical protein binding KCNH2 1 0.46 0.18
42 protein homodimerization activity KCNH2 1 0.48 0.17
43 ATP binding KCNJ11 1 0.87 0.24



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.