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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01244


50 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization KCNH2;KCNQ1 2 0.00057 0.02
2 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity PDE1B;PDE1A 2 0.00086 0.01
3 scaffold protein binding KCNH2;CACNA1H;KCNQ1 3 0.00093 0.048
4 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization KCNQ1 1 0.018 0.023
5 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity PDE1B 1 0.018 0.014
6 delayed rectifier potassium channel activity KCNH2;KCNQ1 2 0.019 0.02
7 metal ion binding PDE1B;CACNA1H;CACNA1A;CACNA2D2;PDE1A 5 0.019 0.19
8 C3HC4-type RING finger domain binding KCNH2 1 0.02 0.019
9 protein phosphatase 1 binding KCNQ1 1 0.02 0.018
10 N-terminal myristoylation domain binding CALM1 1 0.02 0.024
11 troponin I binding TNNC1 1 0.021 0.0091
12 voltage-gated potassium channel activity KCNH2;KCNQ1 2 0.021 0.032
13 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization KCNQ1 1 0.022 0.013
14 phosphorelay sensor kinase activity KCNH2 1 0.024 0.023
15 protein kinase A regulatory subunit binding KCNQ1 1 0.025 0.02
16 low voltage-gated calcium channel activity CACNA1H 1 0.025 0.023
17 troponin T binding TNNC1 1 0.025 0.011
18 voltage-gated calcium channel activity CACNA1A;CACNA2D2 2 0.025 0.033
19 ion channel binding KCNQ1;CALM1 2 0.026 0.054
20 titin binding CALM1 1 0.027 0.021
21 protein phosphatase activator activity CALM1 1 0.027 0.022
22 sodium ion binding ATP1A1 1 0.031 0.021
23 outward rectifier potassium channel activity KCNQ1 1 0.031 0.0091
24 thioesterase binding CALM1 1 0.034 0.032
25 nitric-oxide synthase regulator activity CALM1 1 0.034 0.045
26 steroid hormone binding ATP1A1 1 0.035 0.021
27 phospholipase binding CALM1 1 0.039 0.024
28 phosphatase activity ATP1A1 1 0.041 0.021
29 syntaxin binding CACNA1A 1 0.041 0.021
30 potassium ion binding ATP1A1 1 0.043 0.019
31 phosphatidylinositol-4,5-bisphosphate binding KCNQ1 1 0.044 0.025
32 protein serine/threonine kinase activator activity CALM1 1 0.044 0.019
33 protein kinase A catalytic subunit binding KCNQ1 1 0.048 0.019
34 high voltage-gated calcium channel activity CACNA1A 1 0.05 0.019
35 3',5'-cyclic-AMP phosphodiesterase activity PDE1B 1 0.05 0.02
36 actin filament binding TNNC1 1 0.06 0.03
37 inward rectifier potassium channel activity KCNH2 1 0.06 0.02
38 calcium channel regulator activity CACNA2D2 1 0.061 0.019
39 chaperone binding ATP1A1 1 0.076 0.02
40 ADP binding ATP1A1 1 0.078 0.022
41 sodium ATP1A1 1 0.078 0.019
42 calcium-dependent protein binding TNNC1 1 0.078 0.025
43 calcium ion binding TNNC1;CALM1 2 0.12 0.12
44 protein domain specific binding CALM1 1 0.12 0.034
45 calmodulin binding KCNQ1 1 0.15 0.033
46 protein homodimerization activity KCNH2;TNNC1 2 0.16 0.17
47 ubiquitin protein ligase binding KCNH2 1 0.2 0.069
48 protein kinase binding CALM1 1 0.3 0.089
49 identical protein binding KCNH2 1 0.48 0.17
50 ATP binding ATP1A1 1 0.89 0.24



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.