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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB05964


12 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 monoamine transmembrane transporter activity SLC6A4;SLC6A2 2 9.1E-5 0.039
2 norepinephrine SLC6A2 1 0.0032 0.071
3 cocaine binding SLC6A4 1 0.0032 0.037
4 serotonin SLC6A4 1 0.0043 0.047
5 serotonin transmembrane transporter activity SLC6A4 1 0.0051 0.031
6 dopamine neurotransmitter receptor activity, coupled via Gi/Go DRD2 1 0.0064 0.039
7 Rab GTPase binding SLC6A4 1 0.011 0.031
8 dopamine binding DRD2 1 0.013 0.059
9 actin filament binding SLC6A4 1 0.018 0.041
10 potassium channel regulator activity DRD2 1 0.018 0.051
11 drug binding DRD2 1 0.074 0.19
12 identical protein binding DRD2 1 0.17 0.18



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.