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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00629


10 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 alpha2-adrenergic receptor activity ADRA2A;ADRA2B 2 7.6E-6 0.046
2 epinephrine binding ADRA2A;ADRA2B 2 1.9E-5 0.054
3 heterotrimeric G-protein binding ADRA2A 1 0.0018 0.086
4 alpha-1B adrenergic receptor binding ADRA2A 1 0.0018 0.058
5 alpha-2C adrenergic receptor binding ADRA2A 1 0.0028 0.051
6 norepinephrine binding ADRA2A 1 0.0047 0.054
7 thioesterase binding ADRA2A 1 0.0051 0.046
8 protein heterodimerization activity ADRA2A 1 0.066 0.098
9 protein kinase binding ADRA2A 1 0.072 0.098
10 protein homodimerization activity ADRA2A 1 0.13 0.16



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.