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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00392


9 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 G-protein coupled acetylcholine receptor activity CHRM2;CHRM1 2 6.9E-5 0.042
2 drug binding CHRM2;CHRM1 2 0.0064 0.19
3 protein phosphatase 2A binding GRIN3A 1 0.0064 0.046
4 NMDA glutamate receptor activity GRIN3A 1 0.019 0.044
5 phosphatidylinositol phospholipase C activity CHRM1 1 0.021 0.042
6 glycine binding GRIN3A 1 0.021 0.042
7 calcium channel activity GRIN3A 1 0.024 0.039
8 extracellular-glutamate-gated ion channel activity GRIN3A 1 0.024 0.039
9 identical protein binding GRIN3A 1 0.17 0.19



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.