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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00411


16 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 G-protein coupled acetylcholine receptor activity CHRM3;CHRM4;CHRM1;CHRM2 4 4.6E-10 0.042
2 acetylcholine binding CHRM3;CHRNA2;ACHE 3 1.6E-5 0.047
3 drug binding CHRM3;CHRNA2;CHRM1;CHRM2 4 2.0E-5 0.19
4 phosphatidylinositol phospholipase C activity CHRM3;CHRM1 2 0.00083 0.044
5 cholinesterase activity ACHE 1 0.0098 0.035
6 acetylcholinesterase activity ACHE 1 0.0098 0.032
7 serine hydrolase activity ACHE 1 0.011 0.11
8 laminin binding ACHE 1 0.021 0.058
9 guanyl-nucleotide exchange factor activity CHRM4 1 0.023 0.074
10 beta-amyloid binding ACHE 1 0.027 0.046
11 acetylcholine receptor activity CHRNA2 1 0.034 0.05
12 hydrolase activity ACHE 1 0.039 0.041
13 acetylcholine-activated cation-selective channel activity CHRNA2 1 0.042 0.032
14 collagen binding ACHE 1 0.048 0.042
15 receptor activity CHRM3 1 0.12 0.061
16 protein homodimerization activity ACHE 1 0.34 0.17



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.