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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00925


25 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 epinephrine binding ADRA2A;ADRB2;ADRA2B;ADRA2C 4 1.0E-8 0.053
2 alpha2-adrenergic receptor activity ADRA2A;ADRA2B;ADRA2C 3 1.3E-7 0.051
3 alpha1-adrenergic receptor activity ADRA1A;ADRA1B;ADRA1D 3 1.3E-7 0.048
4 protein heterodimerization activity ADRA2A;ADRA1B;ADRA1A;ADRA2C 4 0.00019 0.1
5 norepinephrine binding ADRA2A;ADRB2 2 0.00021 0.058
6 thioesterase binding ADRA2A;CALM1 2 0.00029 0.048
7 beta2-adrenergic receptor activity ADRB2 1 0.0071 0.06
8 alpha-1B adrenergic receptor binding ADRA2A 1 0.0071 0.049
9 N-terminal myristoylation domain binding CALM1 1 0.0079 0.068
10 heterotrimeric G-protein binding ADRA2A 1 0.0089 0.053
11 protein phosphatase activator activity CALM1 1 0.012 0.049
12 alpha-2C adrenergic receptor binding ADRA2A 1 0.012 0.049
13 titin binding CALM1 1 0.016 0.049
14 alpha-2A adrenergic receptor binding ADRA2C 1 0.022 0.048
15 nitric-oxide synthase regulator activity CALM1 1 0.022 0.056
16 protein homodimerization activity ADRA2A;ADRB2;ADRA2C 3 0.024 0.16
17 phospholipase binding CALM1 1 0.025 0.046
18 protein serine/threonine kinase activator activity CALM1 1 0.03 0.046
19 dopamine binding ADRB2 1 0.03 0.061
20 protein kinase binding ADRA2A;CALM1 2 0.033 0.095
21 potassium channel regulator activity ADRB2 1 0.047 0.053
22 protein domain specific binding CALM1 1 0.094 0.048
23 ion channel binding CALM1 1 0.098 0.061
24 drug binding ADRB2 1 0.18 0.19
25 calcium ion binding CALM1 1 0.37 0.12



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.