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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01392


33 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 inward rectifier potassium channel activity KCNJ14;KCNJ8;KCNJ15;KCNJ1;KCNJ12;KCNJ10 6 1.5E-9 0.061
2 serotonin receptor activity HTR1D;HTR1B;HTR1A;HTR2A;HTR2B;HTR2C 6 5.4E-9 0.053
3 serotonin binding HTR1B;HTR1D;HTR2A;HTR2B;HTR2C 5 8.1E-9 0.055
4 ATP-activated inward rectifier potassium channel activity KCNJ11;KCNJ8;KCNJ10;KCNJ1 4 9.8E-9 0.05
5 alpha2-adrenergic receptor activity ADRA2A;ADRA2B;ADRA2C 3 1.5E-6 0.048
6 drug binding HTR2C;HTR1B;DRD2;HTR2B;HTR2A;DRD3 6 1.0E-5 0.19
7 epinephrine binding ADRA2A;ADRA2B;ADRA2C 3 2.1E-5 0.057
8 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding HTR2C;HTR2A 2 0.00016 0.045
9 dopamine neurotransmitter receptor activity, coupled via Gi/Go DRD2;DRD3 2 0.00043 0.046
10 G-protein activated inward rectifier potassium channel activity KCNJ15;KCNJ10 2 0.0019 0.042
11 dopamine binding DRD2;DRD3 2 0.0032 0.06
12 Gq/11-coupled serotonin receptor activity HTR2C 1 0.015 0.057
13 alpha-1B adrenergic receptor binding ADRA2A 1 0.015 0.048
14 heterotrimeric G-protein binding ADRA2A 1 0.016 0.051
15 alpha-2C adrenergic receptor binding ADRA2A 1 0.028 0.048
16 G-protein alpha-subunit binding HTR2B 1 0.039 0.048
17 norepinephrine binding ADRA2A 1 0.047 0.057
18 G-protein coupled amine receptor activity DRD3 1 0.047 0.056
19 thioesterase binding ADRA2A 1 0.052 0.048
20 alpha-2A adrenergic receptor binding ADRA2C 1 0.052 0.046
21 ankyrin binding KCNJ11 1 0.06 0.057
22 potassium ion binding KCNJ11 1 0.066 0.071
23 phosphatidylinositol-4,5-bisphosphate binding KCNJ1 1 0.072 0.05
24 GTPase activator activity HTR2B 1 0.077 0.069
25 protein heterodimerization activity ADRA2A;ADRA2C 2 0.11 0.1
26 potassium channel regulator activity DRD2 1 0.11 0.054
27 voltage-gated potassium channel activity KCNJ11 1 0.16 0.045
28 virus receptor activity HTR2A 1 0.21 0.053
29 ion channel binding KCNJ11 1 0.22 0.059
30 protein homodimerization activity ADRA2A;ADRA2C 2 0.38 0.17
31 protein kinase binding ADRA2A 1 0.48 0.094
32 ATP binding KCNJ11;KCNJ8;KCNJ10;KCNJ1 4 0.52 0.24
33 identical protein binding DRD2 1 0.68 0.18



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.