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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01622


14 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 alpha1-adrenergic receptor activity ADRA1A;ADRA1B 2 0.00016 0.061
2 dopamine binding DRD1;DRD2 2 0.00074 0.062
3 drug binding DRD1;DRD2;HTR2A 3 0.0011 0.19
4 serotonin receptor activity HTR1A;HTR2A 2 0.0018 0.056
5 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding HTR2A 1 0.01 0.07
6 dopamine neurotransmitter receptor activity, coupled via Gs DRD1 1 0.01 0.092
7 dopamine neurotransmitter receptor activity, coupled via Gi/Go DRD2 1 0.011 0.061
8 dopamine neurotransmitter receptor activity DRD1 1 0.011 0.076
9 G-protein coupled amine receptor activity DRD1 1 0.013 0.076
10 protein heterodimerization activity ADRA1A;ADRA1B 2 0.014 0.1
11 serotonin binding HTR2A 1 0.024 0.067
12 potassium channel regulator activity DRD2 1 0.035 0.061
13 virus receptor activity HTR2A 1 0.067 0.056
14 identical protein binding DRD2 1 0.32 0.18



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.