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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB09167


32 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 G-protein coupled acetylcholine receptor activity CHRM3;CHRM2;CHRM4;CHRM1;CHRM5 5 9.7E-11 0.048
2 alpha2-adrenergic receptor activity ADRA2A;ADRA2B;ADRA2C 3 1.6E-6 0.055
3 alpha1-adrenergic receptor activity ADRA1A;ADRA1B;ADRA1D 3 1.6E-6 0.046
4 epinephrine binding ADRA2A;ADRA2B;ADRA2C 3 2.4E-5 0.053
5 phosphatidylinositol phospholipase C activity CHRM3;CHRM1;CHRM5 3 0.00016 0.052
6 monoamine transmembrane transporter activity SLC6A4;SLC6A2 2 0.0016 0.046
7 drug binding CHRM3;CHRM1;HTR2A;CHRM2 4 0.0018 0.19
8 protein heterodimerization activity ADRA2A;ADRA1B;ADRA1A;ADRA2C 4 0.0027 0.094
9 cocaine binding SLC6A4 1 0.013 0.098
10 alpha-1B adrenergic receptor binding ADRA2A 1 0.013 0.062
11 serotonin receptor activity HTR1A;HTR2A 2 0.014 0.05
12 norepinephrine SLC6A2 1 0.014 0.19
13 serotonin SLC6A4 1 0.015 0.13
14 heterotrimeric G-protein binding ADRA2A 1 0.017 0.068
15 alpha-2C adrenergic receptor binding ADRA2A 1 0.021 0.062
16 serotonin transmembrane transporter activity SLC6A4 1 0.021 0.083
17 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding HTR2A 1 0.023 0.047
18 histamine binding HRH1 1 0.03 0.059
19 norepinephrine binding ADRA2A 1 0.038 0.053
20 histamine receptor activity HRH1 1 0.041 0.049
21 thioesterase binding ADRA2A 1 0.041 0.053
22 alpha-2A adrenergic receptor binding ADRA2C 1 0.043 0.05
23 Rab GTPase binding SLC6A4 1 0.045 0.074
24 guanyl-nucleotide exchange factor activity CHRM4 1 0.045 0.074
25 serotonin binding HTR2A 1 0.064 0.051
26 actin filament binding SLC6A4 1 0.088 0.055
27 acetylcholine binding CHRM3 1 0.091 0.051
28 virus receptor activity HTR2A 1 0.18 0.05
29 G-protein coupled receptor activity HRH1 1 0.25 0.06
30 receptor activity CHRM3 1 0.29 0.061
31 protein homodimerization activity ADRA2A;ADRA2C 2 0.31 0.16
32 protein kinase binding ADRA2A 1 0.41 0.088



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.