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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB09304


25 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 serotonin receptor activity HTR3E;HTR3D;HTR4;HTR3B;HTR3A;HTR1B;HTR1A;HTR3C;HTR1D;HTR2C;HTR2A;HTR6;HTR1F;HTR7;HTR2B;HTR1E 16 6.0E-37 0.053
2 serotonin binding HTR2A;HTR3A;HTR1B;HTR1D;HTR2C;HTR1F;HTR2B;HTR1E 8 9.0E-17 0.056
3 serotonin-activated cation-selective channel activity HTR3A;HTR3D;HTR3E;HTR3C;HTR3B 5 6.7E-11 0.089
4 alpha2-adrenergic receptor activity ADRA2A;ADRA2B;ADRA2C 3 1.6E-6 0.057
5 epinephrine binding ADRA2A;ADRA2B;ADRA2C 3 2.6E-5 0.055
6 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding HTR2C;HTR2A 2 0.00018 0.044
7 drug binding HTR1B;HTR2A;HTR2B;HTR2C 4 0.0028 0.19
8 Gq/11-coupled serotonin receptor activity HTR2C 1 0.017 0.081
9 alpha-1B adrenergic receptor binding ADRA2A 1 0.017 0.062
10 heterotrimeric G-protein binding ADRA2A 1 0.019 0.071
11 alpha-2C adrenergic receptor binding ADRA2A 1 0.031 0.06
12 G-protein alpha-subunit binding HTR2B 1 0.042 0.057
13 norepinephrine binding ADRA2A 1 0.052 0.058
14 thioesterase binding ADRA2A 1 0.052 0.053
15 alpha-2A adrenergic receptor binding ADRA2C 1 0.052 0.049
16 histamine receptor activity HTR6 1 0.056 0.044
17 ion channel activity HTR3B 1 0.059 0.096
18 GTPase activator activity HTR2B 1 0.082 0.081
19 protein heterodimerization activity ADRA2A;ADRA2C 2 0.12 0.096
20 voltage-gated potassium channel activity HTR3A 1 0.17 0.046
21 virus receptor activity HTR2A 1 0.22 0.053
22 G-protein coupled receptor activity HTR1E 1 0.3 0.063
23 receptor activity HTR3A 1 0.34 0.063
24 protein homodimerization activity ADRA2A;ADRA2C 2 0.39 0.16
25 protein kinase binding ADRA2A 1 0.47 0.091



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.