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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00797


15 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 alpha2-adrenergic receptor activity ADRA2A;ADRA2B;ADRA2C 3 8.1E-8 0.057
2 epinephrine binding ADRA2A;ADRA2B;ADRA2C 3 8.1E-7 0.052
3 histamine receptor activity HRH2;HRH1 2 0.00019 0.042
4 protein heterodimerization activity ADRA2A;ADRA1A;ADRA2C 3 0.0013 0.094
5 heterotrimeric G-protein binding ADRA2A 1 0.0053 0.13
6 alpha-1B adrenergic receptor binding ADRA2A 1 0.0053 0.087
7 alpha-2C adrenergic receptor binding ADRA2A 1 0.0092 0.073
8 alpha1-adrenergic receptor activity ADRA1A 1 0.011 0.042
9 histamine binding HRH1 1 0.011 0.061
10 norepinephrine binding ADRA2A 1 0.013 0.052
11 alpha-2A adrenergic receptor binding ADRA2C 1 0.013 0.044
12 thioesterase binding ADRA2A 1 0.013 0.05
13 protein homodimerization activity ADRA2A;ADRA2C 2 0.066 0.16
14 G-protein coupled receptor activity HRH1 1 0.099 0.063
15 protein kinase binding ADRA2A 1 0.18 0.092



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.