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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB11273


35 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 serotonin receptor activity HTR3E;HTR3D;HTR4;HTR3B;HTR3A;HTR1B;HTR1A;HTR3C;HTR1D;HTR2C;HTR2A;HTR6;HTR1F;HTR7;HTR2B;HTR1E 16 1.8E-33 0.05
2 serotonin binding HTR2A;HTR3A;HTR1B;HTR1D;HTR2C;HTR1F;HTR2B;HTR1E 8 1.8E-15 0.053
3 epinephrine binding ADRA2A;ADRA2C;ADRB2;ADRB3;ADRB1;ADRA2B 6 3.1E-12 0.051
4 serotonin-activated cation-selective channel activity HTR3A;HTR3D;HTR3E;HTR3C;HTR3B 5 3.2E-10 0.089
5 norepinephrine binding ADRB1;ADRA2A;ADRB2;ADRB3 4 3.4E-8 0.053
6 alpha1-adrenergic receptor activity ADRA1A;ADRA1B;ADRA1D 3 3.1E-6 0.04
7 alpha2-adrenergic receptor activity ADRA2A;ADRA2B;ADRA2C 3 3.1E-6 0.051
8 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding HTR2C;HTR2A 2 0.0003 0.04
9 beta-adrenergic receptor activity ADRB1;ADRB3 2 0.0003 0.06
10 drug binding HTR1B;ADRB2;HTR2A;HTR2B;HTR2C 5 0.00074 0.19
11 protein heterodimerization activity ADRB1;ADRA2A;ADRA1B;ADRA1A;ADRA2C 5 0.0013 0.093
12 alpha-2A adrenergic receptor binding ADRB1;ADRA2C 2 0.0022 0.046
13 alpha-1B adrenergic receptor binding ADRA2A 1 0.016 0.051
14 Ras guanyl-nucleotide exchange factor activity ADRB1 1 0.016 0.063
15 beta2-adrenergic receptor activity ADRB2 1 0.017 0.06
16 beta1-adrenergic receptor activity ADRB1 1 0.018 0.066
17 Gq/11-coupled serotonin receptor activity HTR2C 1 0.019 0.078
18 beta3-adrenergic receptor activity ADRB3 1 0.021 0.089
19 heterotrimeric G-protein binding ADRA2A 1 0.022 0.054
20 alpha-2C adrenergic receptor binding ADRA2A 1 0.031 0.051
21 G-protein alpha-subunit binding HTR2B 1 0.044 0.051
22 histamine receptor activity HTR6 1 0.067 0.042
23 thioesterase binding ADRA2A 1 0.067 0.048
24 ion channel activity HTR3B 1 0.076 0.11
25 dopamine binding ADRB2 1 0.097 0.059
26 GTPase activator activity HTR2B 1 0.1 0.09
27 protein homodimerization activity ADRA2A;ADRB2;ADRB3;ADRA2C 4 0.11 0.16
28 receptor signaling protein activity ADRB1 1 0.12 0.05
29 potassium channel regulator activity ADRB2 1 0.14 0.051
30 PDZ domain binding ADRB1 1 0.19 0.041
31 voltage-gated potassium channel activity HTR3A 1 0.2 0.044
32 virus receptor activity HTR2A 1 0.26 0.05
33 G-protein coupled receptor activity HTR1E 1 0.35 0.059
34 receptor activity HTR3A 1 0.4 0.06
35 protein kinase binding ADRA2A 1 0.57 0.088



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.