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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01577


28 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 monoamine transmembrane transporter activity SLC6A4;SLC18A2;SLC6A2;SLC6A3;SLC18A1 5 8.9E-12 0.04
2 alpha2-adrenergic receptor activity ADRA2A;ADRA2B;ADRA2C 3 6.3E-7 0.039
3 epinephrine binding ADRA2A;ADRA2B;ADRA2C 3 8.3E-6 0.046
4 serotonin transmembrane transporter activity SLC6A4;SLC18A1 2 9.8E-5 0.036
5 primary amine oxidase activity MAOB;MAOA 2 0.00078 0.054
6 cocaine binding SLC6A4 1 0.0084 0.038
7 alpha-1B adrenergic receptor binding ADRA2A 1 0.0084 0.038
8 norepinephrine SLC6A2 1 0.0091 0.047
9 serotonin SLC6A4 1 0.01 0.041
10 flavin adenine dinucleotide binding MAOB;MAOA 2 0.01 0.046
11 trace-amine receptor activity TAAR1 1 0.011 0.018
12 dopamine transmembrane transporter activity SLC6A3 1 0.012 0.057
13 dopamine SLC6A3 1 0.014 0.057
14 alpha-2C adrenergic receptor binding ADRA2A 1 0.015 0.038
15 heterotrimeric G-protein binding ADRA2A 1 0.016 0.04
16 drug transmembrane transporter activity SLC18A1 1 0.021 0.018
17 norepinephrine binding ADRA2A 1 0.026 0.049
18 alpha-2A adrenergic receptor binding ADRA2C 1 0.029 0.038
19 thioesterase binding ADRA2A 1 0.029 0.038
20 Rab GTPase binding SLC6A4 1 0.033 0.036
21 dopamine binding SLC6A3 1 0.041 0.057
22 protein heterodimerization activity ADRA2A;ADRA2C 2 0.042 0.091
23 serotonin binding MAOA 1 0.042 0.048
24 actin filament binding SLC6A4 1 0.058 0.039
25 protein homodimerization activity ADRA2A;ADRA2C 2 0.18 0.16
26 G-protein coupled receptor activity TAAR1 1 0.18 0.057
27 electron carrier activity MAOB 1 0.21 0.046
28 protein kinase binding ADRA2A 1 0.31 0.086



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.