QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics   |  Return to main result page

GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

Results: help


Download results

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01363


35 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 epinephrine binding ADRA2A;ADRA2C;ADRB2;ADRB3;ADRB1;ADRA2B 6 8.9E-14 0.045
2 monoamine transmembrane transporter activity SLC6A4;SLC18A2;SLC6A2;SLC6A3;SLC18A1 5 1.6E-11 0.038
3 norepinephrine binding ADRB1;ADRA2A;ADRB2;ADRB3 4 3.2E-9 0.047
4 alpha2-adrenergic receptor activity ADRA2A;ADRA2B;ADRA2C 3 6.8E-7 0.038
5 beta-adrenergic receptor activity ADRB1;ADRB3 2 0.00012 0.039
6 serotonin transmembrane transporter activity SLC6A4;SLC18A1 2 0.00012 0.045
7 alpha-2A adrenergic receptor binding ADRB1;ADRA2C 2 0.00086 0.037
8 primary amine oxidase activity MAOB;MAOA 2 0.00086 0.068
9 dopamine binding ADRB2;SLC6A3 2 0.0021 0.055
10 cocaine binding SLC6A4 1 0.0077 0.047
11 alpha-1B adrenergic receptor binding ADRA2A 1 0.0077 0.036
12 Ras guanyl-nucleotide exchange factor activity ADRB1 1 0.0081 0.039
13 beta2-adrenergic receptor activity ADRB2 1 0.0085 0.039
14 norepinephrine SLC6A2 1 0.009 0.059
15 serotonin SLC6A4 1 0.0095 0.052
16 dopamine transmembrane transporter activity SLC6A3 1 0.01 0.072
17 beta1-adrenergic receptor activity ADRB1 1 0.011 0.039
18 flavin adenine dinucleotide binding MAOB;MAOA 2 0.011 0.046
19 beta3-adrenergic receptor activity ADRB3 1 0.012 0.096
20 dopamine SLC6A3 1 0.012 0.072
21 protein homodimerization activity ADRA2A;ADRB2;ADRB3;ADRA2C 4 0.013 0.16
22 alpha-2C adrenergic receptor binding ADRA2A 1 0.013 0.036
23 heterotrimeric G-protein binding ADRA2A 1 0.014 0.037
24 protein heterodimerization activity ADRB1;ADRA2A;ADRA2C 3 0.015 0.093
25 drug transmembrane transporter activity SLC18A1 1 0.019 0.045
26 thioesterase binding ADRA2A 1 0.031 0.037
27 Rab GTPase binding SLC6A4 1 0.036 0.042
28 serotonin binding MAOA 1 0.051 0.047
29 receptor signaling protein activity ADRB1 1 0.06 0.038
30 actin filament binding SLC6A4 1 0.068 0.038
31 potassium channel regulator activity ADRB2 1 0.071 0.045
32 PDZ domain binding ADRB1 1 0.097 0.037
33 electron carrier activity MAOB 1 0.25 0.044
34 drug binding ADRB2 1 0.27 0.19
35 protein kinase binding ADRA2A 1 0.35 0.088



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.