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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01149


36 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 monoamine transmembrane transporter activity SLC6A4;SLC6A2;SLC6A3 3 1.2E-5 0.04
2 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding HTR2C;HTR2A 2 0.00021 0.041
3 serotonin receptor activity HTR1A;HTR2A;HTR2C 3 0.00026 0.05
4 alpha1-adrenergic receptor activity ADRA1A;ADRA1B 2 0.00031 0.04
5 serotonin binding HTR2C;HTR2A 2 0.0029 0.052
6 cocaine binding SLC6A4 1 0.0092 0.049
7 alpha-1B adrenergic receptor binding ADRA2A 1 0.0092 0.039
8 norepinephrine SLC6A2 1 0.0099 0.061
9 serotonin SLC6A4 1 0.011 0.053
10 protein heterodimerization activity ADRA2A;ADRA1B;ADRA1A 3 0.012 0.096
11 dopamine transmembrane transporter activity SLC6A3 1 0.012 0.1
12 Gq/11-coupled serotonin receptor activity HTR2C 1 0.013 0.036
13 serotonin transmembrane transporter activity SLC6A4 1 0.013 0.041
14 C3HC4-type RING finger domain binding KCNH2 1 0.013 0.067
15 phosphorelay sensor kinase activity KCNH2 1 0.014 0.08
16 dopamine SLC6A3 1 0.014 0.15
17 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization KCNH2 1 0.015 0.067
18 alpha-2C adrenergic receptor binding ADRA2A 1 0.016 0.039
19 heterotrimeric G-protein binding ADRA2A 1 0.016 0.041
20 alpha2-adrenergic receptor activity ADRA2A 1 0.019 0.041
21 norepinephrine binding ADRA2A 1 0.024 0.052
22 thioesterase binding ADRA2A 1 0.029 0.042
23 Rab GTPase binding SLC6A4 1 0.031 0.036
24 epinephrine binding ADRA2A 1 0.031 0.052
25 drug binding HTR2C;HTR2A 2 0.032 0.19
26 dopamine binding SLC6A3 1 0.039 0.059
27 actin filament binding SLC6A4 1 0.058 0.041
28 inward rectifier potassium channel activity KCNH2 1 0.058 0.039
29 voltage-gated potassium channel activity KCNH2 1 0.091 0.042
30 delayed rectifier potassium channel activity KCNH2 1 0.091 0.044
31 scaffold protein binding KCNH2 1 0.092 0.05
32 virus receptor activity HTR2A 1 0.11 0.052
33 protein homodimerization activity ADRA2A;KCNH2 2 0.16 0.16
34 ubiquitin protein ligase binding KCNH2 1 0.2 0.07
35 protein kinase binding ADRA2A 1 0.29 0.09
36 identical protein binding KCNH2 1 0.47 0.17



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.