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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical-target; # of predictions: 20; Secondary interactions: yes
Input drug 1: Loxapine
Input target 1: ADA2A


50 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT) p-value (EPD)
1 serotonin receptor activity HTR2A;HTR1D;HTR3A;HTR1B;HTR1A;HTR1E;HTR2C;HTR5A;HTR6;HTR7 10 7.2E-15 0.048
2 dopamine binding DRD5;DRD1;DRD3;DRD4;DRD2;SLC6A3 6 9.2E-10 0.057
3 serotonin binding HTR1E;HTR3A;HTR1B;HTR2A;HTR1D;HTR2C 6 1.7E-9 0.05
4 G-protein coupled acetylcholine receptor activity CHRM3;CHRM2;CHRM4;CHRM1;CHRM5 5 1.7E-9 0.042
5 drug binding CHRM2;DRD4;HTR1B;DRD2;DRD1;CHRM1;HTR2A;CHRM3;DRD3;HTR2C 10 9.4E-9 0.19
6 G-protein coupled amine receptor activity DRD1;DRD3;DRD5;DRD4 4 1.2E-7 0.048
7 histamine receptor activity HRH2;HTR6;HRH1;HRH4 4 4.9E-7 0.042
8 epinephrine binding ADRB1;ADRA2A;ADRA2B;ADRA2C 4 1.3E-6 0.049
9 alpha2-adrenergic receptor activity ADRA2A;ADRA2B;ADRA2C 3 6.1E-6 0.045
10 dopamine neurotransmitter receptor activity DRD1;DRD5;DRD4 3 6.1E-6 0.051
11 dopamine neurotransmitter receptor activity, coupled via Gi/Go DRD2;DRD3;DRD4 3 6.7E-6 0.04
12 monoamine transmembrane transporter activity SLC6A4;SLC6A2;SLC6A3 3 5.5E-5 0.04
13 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding HTR2C;HTR2A 2 0.00045 0.04
14 dopamine neurotransmitter receptor activity, coupled via Gs DRD1;DRD5 2 0.00045 0.068
15 phosphatidylinositol phospholipase C activity CHRM3;CHRM1;CHRM5 3 0.0007 0.047
16 histamine binding HRH4;HRH1 2 0.0011 0.046
17 alpha1-adrenergic receptor activity ADRA1A;ADRA1B 2 0.0011 0.04
18 norepinephrine binding ADRB1;ADRA2A 2 0.0021 0.048
19 alpha-2A adrenergic receptor binding ADRB1;ADRA2C 2 0.0032 0.043
20 protein heterodimerization activity ADRB1;ADRA2A;ADRA1B;ADRA1A;ADRA2C 5 0.0034 0.094
21 Ras guanyl-nucleotide exchange factor activity ADRB1 1 0.018 0.046
22 cocaine binding SLC6A4 1 0.018 0.076
23 alpha-1B adrenergic receptor binding ADRA2A 1 0.019 0.044
24 norepinephrine SLC6A2 1 0.02 0.12
25 serotonin SLC6A4 1 0.02 0.099
26 dopamine transmembrane transporter activity SLC6A3 1 0.021 0.14
27 beta1-adrenergic receptor activity ADRB1 1 0.022 0.047
28 Gq/11-coupled serotonin receptor activity HTR2C 1 0.023 0.059
29 dopamine SLC6A3 1 0.024 0.14
30 heterotrimeric G-protein binding ADRA2A 1 0.025 0.045
31 potassium channel regulator activity DRD2;DRD4 2 0.025 0.048
32 beta-adrenergic receptor activity ADRB1 1 0.033 0.048
33 serotonin transmembrane transporter activity SLC6A4 1 0.033 0.065
34 alpha-2C adrenergic receptor binding ADRA2A 1 0.034 0.044
35 serotonin-activated cation-selective channel activity HTR3A 1 0.077 0.2
36 thioesterase binding ADRA2A 1 0.077 0.044
37 Rab GTPase binding SLC6A4 1 0.088 0.055
38 guanyl-nucleotide exchange factor activity CHRM4 1 0.088 0.046
39 G-protein coupled receptor activity HRH1;HTR1E 2 0.12 0.058
40 receptor signaling protein activity ADRB1 1 0.15 0.046
41 receptor activity HTR3A;CHRM3 2 0.15 0.059
42 actin filament binding SLC6A4 1 0.16 0.045
43 SH3 domain binding DRD4 1 0.16 0.085
44 acetylcholine binding CHRM3 1 0.17 0.048
45 PDZ domain binding ADRB1 1 0.23 0.041
46 voltage-gated potassium channel activity HTR3A 1 0.24 0.042
47 virus receptor activity HTR2A 1 0.31 0.048
48 identical protein binding DRD2;DRD4 2 0.62 0.17
49 protein homodimerization activity ADRA2A;ADRA2C 2 0.66 0.16
50 protein kinase binding ADRA2A 1 0.66 0.087



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.